Synthetic cocaine invades Naples. Santo Cosenza, linked to trafficking, has disappeared, jeopardizing the confrontation with the boss Annibale Ruotolo. Pettenella's phone, authorized for control, is not giving signals. Adrianne Ledger, under investigation, has disappeared; Cosenza's fingerprints in her apartment provide a lead. Sciacca, Anna and Demetrio investigate a robbery that took place in a villa where drugs were found.