Peabody and Sherman travel back to the 19th century, hoping to witness the famous meeting between explorer Henry Morton Stanley and missionary David Livingstone. However, Peabody realizes he has missed the encounter and learns that Livingstone is in danger in the African wilderness. Determined to rescue them both, Peabody uses his wits and clever inventions to navigate the challenges of the jungle, ensuring that history remains intact while saving the legendary explorers from peril.